P-Selectivity, Immunity, and the Power of One Bit

We prove that P-sel, the class of all P-selective sets, is EXP-immune, but is not EXP/1-immune. That is, we prove that some infinite P-selective set has no infinite EXP-time subset, but we also prove that every infinite P-selective set has some infinite subset in EXP/1. Informally put, the immunity of P-sel is so fragile that it is pierced by a single bit of information. The above claims follow from broader results that we obtain about the immunity of the P-selective sets. In particular, we prove that for every recursive function f, P-sel is DTIME(f)-immune. Yet we also prove that P-sel is not \Pi_2^p/1-immune

Inadequate food intake at high temperatures is related to depressed mitochondrial respiratory capacity

Animals, especially ectotherms, are highly sensitive to the temperature of their surrounding environment. Extremely high temperature, for example, induces a decline of average performance of conspecifics within a population, but individual heterogeneity in the ability to cope with elevating temperatures has rarely been studied. In this study, we examined inter-individual variation in feeding ability and consequent growth rate of juvenile brown trout Salmo trutta acclimated to a high temperature (19°C), and investigated the relationship between these metrics of whole-animal performances and among-individual variation in mitochondrial respiration capacity. Food was provided ad libitum yet intake varied ten-fold amongst individuals, resulting in some fish losing weight whilst others continued to grow. Almost half of the variation in food intake was related to variability in mitochondrial capacity: low intake (and hence growth failure) was associated with high leak respiration rates within liver and muscle mitochondria, and a lower coupling of muscle mitochondria. These observations, combined with the inability of fish with low food consumption to increase their intake despite ad libitum food levels, suggest a possible insufficient capacity of the mitochondria for maintaining ATP homeostasis. Individual variation in thermal performance is likely to confer variation in the upper limit of an organism's thermal niche and in turn affect the structure of wild populations in warming environments

Relatively computably enumerable reals

A real X is defined to be relatively c.e. if there is a real Y such that X is c.e.(Y) and Y does not compute X. A real X is relatively simple and above if there is a real Y <_T X such that X is c.e.(Y) and there is no infinite subset Z of the complement of X such that Z is c.e.(Y). We prove that every nonempty Pi^0_1 class contains a member which is not relatively c.e. and that every 1-generic real is relatively simple and above.Comment: 5 pages. Significant changes from earlier versio

RITUXIMAB DELAYS WOUND HEALING AND DECREASES WHITE BLOOD CELL COUNT IN MALE MICE

ABSTRACTObjective: The aims of this research are to evaluate the effect of rituximab on wound healing, some hematological parameters, histological changes inwound healing, and histopathological changes in some organs in male mice.Methods: Totally, 15 adult male mice (25-30 g) were enrolled in this study. Animals were kept in the animal house College of Medicine/Universityof Babylon, and the temperature was controlled on 25°C and 14 hrs light and 10 hrs dark cycles. The animals were provided with standard diet andwater ad libitum. The animals were divided randomly into 3 groups, five mice in each group, Group 1 (control group) received no treatment, Group 2received rituximab 1 m/kg, IP, at days 0, 5, and 10 after wounding, in Group 3, rituximab was topically applied to the wound at days 0, 5, and 10 afterwounding.Results: The results yield that the wound healing significantly decreased (p&lt;0.05) in Groups 2 and 3 as compared to control group. While the resultsregarding white blood cells (WBCs) count, there is a significant decrease in WBC count in Group 2 (p&gt;0.05). Platelets and red blood cell count insignificantly increased in Group 3 as compared to control group (p&lt;0.05). There were no histopathological changes in the skin, kidneys, and spleen.In liver, nonsignificant histopathological changes (p&gt;0.05) found in Group 2 and 3 as compared to control group.Conclusion: Rituximab delays wound healing and reduces WBC count in male mice.Keywords: Rituximab, Wound healing, Lymphocyte, CD20, White blood cells, Mice

Behavior of heuristics and state space structure near SAT/UNSAT transition

We study the behavior of ASAT, a heuristic for solving satisfiability problems by stochastic local search near the SAT/UNSAT transition. The heuristic is focused, i.e. only variables in unsatisfied clauses are updated in each step, and is significantly simpler, while similar to, walksat or Focused Metropolis Search. We show that ASAT solves instances as large as one million variables in linear time, on average, up to 4.21 clauses per variable for random 3SAT. For K higher than 3, ASAT appears to solve instances at the ``FRSB threshold'' in linear time, up to K=7.Comment: 12 pages, 6 figures, longer version available as MSc thesis of first author at http://biophys.physics.kth.se/docs/ardelius_thesis.pd

Topology of multiple log transforms of 4-manifolds

Given a 4-manifold X and an imbedding of T^{2} x B^2 into X, we describe an algorithm X --> X_{p,q} for drawing the handlebody of the 4-manifold obtained from X by (p,q)-logarithmic transforms along the parallel tori. By using this algorithm, we obtain a simple handle picture of the Dolgachev surface E(1)_{p,q}, from that we deduce that the exotic copy E(1)_{p,q} # 5(-CP^2) of E(1) # 5(-CP^2) differs from the original one by a codimension zero simply connected Stein submanifold M_{p,q}, which are therefore examples of infinitely many Stein manifolds that are exotic copies of each other (rel boundaries). Furthermore, by a similar method we produce infinitely many simply connected Stein submanifolds Z_{p} of E(1)_{p,2} # 2(-CP^2)$ with the same boundary and the second Betti number 2, which are (absolutely) exotic copies of each other; this provides an alternative proof of a recent theorem of the author and Yasui [AY4]. Also, by using the description of S^2 x S^2 as a union of two cusps glued along their boundaries, and by using this algorithm, we show that multiple log transforms along the tori in these cusps do not change smooth structure of S^2 x S^2.Comment: Updated, with 17 pages 21 figure

Global Commercial Surrogacy and International Adoption: Parallels and Differences

Over the decades, there have been numerous trends in the formation of family for those experiencing infertility. Adoption – initially domestic but now mostly international – has long been a prevailing method, with a dual outcome of also finding homes for parentless children. Those would-be parents with a stronger desire for genetic relatedness have turned to assisted reproductive technologies for the creation of their families. In the 21st century, capitalising on globalisation and advances in medical sciences and communication, global commercial surrogacy (GCS) is emerging as a dominant method of family formation. In seeking to publish this article in Adoption & Fostering, our primary objective was to provide its readership with an introductory look at GCS, thereby expanding an awareness of surrogacy to an audience whose work has traditionally been concerned with the care and protection of children through foster care and adoption. A secondary aim was to see where the long-standing field of adoption could potentially inform the burgeoning field of global commercial surrogacy. To achieve these objectives, we use international adoption and the adoption triangle as a framework, as we look at the similarities and differences between: (1) the adoptive and commissioning parents; (2) the birth mother and the surrogate; and (3) the adopted children and the children born of global surrogacy

The quality of reporting of primary test accuracy studies in obstetrics and gynaecology: application of the STARD criteria

<p>Abstract</p> <p>Background</p> <p>In obstetrics and gynaecology there has been a rapid growth in the development of new tests and primary studies of their accuracy. It is imperative that such studies are reported with transparency allowing the detection of any potential bias that may invalidate the results. The objective of this study was to determine the quality of reporting in diagnostic test accuracy studies in obstetrics and gynaecology using the Standards for Reporting of Diagnostic Accuracy - STARD checklist.</p> <p>Methods</p> <p>The included studies of ten systematic reviews were assessed for compliance with each of the reporting criteria. Using appropriate statistical tests we investigated whether there was an improvement in reporting quality since the introduction of the STARD checklist, whether a correlation existed between study sample size, country of origin of study and reporting quality.</p> <p>Results</p> <p>A total of 300 studies were included (195 for obstetrics, 105 for gynaecology). The overall reporting quality of included studies to the STARD criteria was poor. Obstetric studies reported adequately > 50% of the time for 62.1% (18/29) of the items while gynaecologic studies did the same 51.7% (15/29). There was a greater mean compliance with STARD criteria in the included obstetric studies than the gynaecological (p < 0.0001). There was a positive correlation, in both obstetrics (p < 0.0001) and gynaecology (p = 0.0123), between study sample size and reporting quality. No correlation between geographical area of publication and compliance with the reporting criteria could be demonstrated.</p> <p>Conclusions</p> <p>The reporting quality of papers in obstetrics and gynaecology is improving. This may be due to initiatives such as the STARD checklist as well as historical progress in awareness among authors of the need to accurately report studies. There is however considerable scope for further improvement.</p